In contemporary economics, knowledge is key element for organizational competitiveness. Therefore diverse organizations, especially small and medium-sized companies should have a clear position in their organizations current knowledge in order to survive and achieve accomplishment. The purpose of this study was to present a perspicuous condition of knowledge management strategies in firms, located in Isfahan science and technology town (ISTT). 98 firms were selected in a simple randomized sampling and their managers were requested to answer the questionnaire asking 47 questions about 4 different knowledge strategies, including knowledge application, knowledge transfer, organizational knowledge and producing knowledge. The type of this study is survey research. Data was analyzed by using descriptive statistics (frequency, mean and standard deviation). The results indicate that the dominant strategy of knowledge management in the town in applying knowledge is human-centered strategy, in field of knowledge transfer is social strategy, in the development and producing of knowledge is applied strategies in field of organizational knowledge is innovations strategy. This finding demonstrates that firms’ emphasis on hidden knowledge and their knowledge has more personal nature. It is proposed to modify the existing state that empirical knowledge of personals is written to be easily shared with others.